Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T cells. This could suppress autoimmunity in those at risk for the development of T1D, as well as in those with established disease who receive islet replacement or regeneration therapy. Because functio...

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Vydáno v:Nat Med
Hlavní autoři: Babon, Jenny Aurielle B, DeNicola, Megan E, Blodgett, David M, Crèvecoeur, Inne, Buttrick, Thomas S, Maehr, René, Bottino, Rita, Naji, Ali, Kaddis, John, Elyaman, Wassim, James, Eddie A, Haliyur, Rachana, Brissova, Marcela, Overbergh, Lut, Mathieu, Chantal, Delong, Thomas, Haskins, Kathryn, Pugliese, Alberto, Campbell-Thompson, Martha, Mathews, Clayton, Atkinson, Mark A, Powers, Alvin C, Harlan, David M, Kent, Sally C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140746/
https://ncbi.nlm.nih.gov/pubmed/27798614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4203
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