Immunogenomics of Hypermutated Glioblastoma: a Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy

We present the case of a patient with a left frontal glioblastoma with PNET features and hypermutated genotype in the setting of a POLE germline alteration. During standard-of-care chemoradiation, the patient developed a cervical spine metastasis and was subsequently treated with Pembrolizumab. Shor...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Discov
Egile Nagusiak: Johanns, Tanner M., Miller, Christopher A., Dorward, Ian G., Tsien, Christina, Chang, Edward, Perry, Arie, Uppaluri, Ravindra, Ferguson, Cole, Schmidt, Robert E., Dahiya, Sonika, Ansstas, George, Mardis, Elaine R., Dunn, Gavin P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140283/
https://ncbi.nlm.nih.gov/pubmed/27683556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0575
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