Immunogenomics of Hypermutated Glioblastoma: a Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy

We present the case of a patient with a left frontal glioblastoma with PNET features and hypermutated genotype in the setting of a POLE germline alteration. During standard-of-care chemoradiation, the patient developed a cervical spine metastasis and was subsequently treated with Pembrolizumab. Shor...

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Publicado en:Cancer Discov
Main Authors: Johanns, Tanner M., Miller, Christopher A., Dorward, Ian G., Tsien, Christina, Chang, Edward, Perry, Arie, Uppaluri, Ravindra, Ferguson, Cole, Schmidt, Robert E., Dahiya, Sonika, Ansstas, George, Mardis, Elaine R., Dunn, Gavin P.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140283/
https://ncbi.nlm.nih.gov/pubmed/27683556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0575
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