Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors

BACKGROUND: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with cancer therapies. The consequences of acidity on the...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Faes, Seraina, Duval, Adrian P., Planche, Anne, Uldry, Emilie, Santoro, Tania, Pythoud, Catherine, Stehle, Jean-Christophe, Horlbeck, Janine, Letovanec, Igor, Riggi, Nicolo, Demartines, Nicolas, Dormond, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139076/
https://ncbi.nlm.nih.gov/pubmed/27919264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0562-y
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