Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors

BACKGROUND: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with cancer therapies. The consequences of acidity on the...

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Publicat a:Mol Cancer
Autors principals: Faes, Seraina, Duval, Adrian P., Planche, Anne, Uldry, Emilie, Santoro, Tania, Pythoud, Catherine, Stehle, Jean-Christophe, Horlbeck, Janine, Letovanec, Igor, Riggi, Nicolo, Demartines, Nicolas, Dormond, Olivier
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139076/
https://ncbi.nlm.nih.gov/pubmed/27919264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0562-y
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