SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy

Trehalose is a disaccharide demonstrated to mitigate disease burden in multiple murine neurodegenerative models. We recently revealed that trehalose rapidly induces hepatic autophagy and abrogates hepatic steatosis by inhibiting hexose transport via the SLC2A family of facilitative transporters. Pri...

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Udgivet i:Sci Rep
Main Authors: Mayer, Allyson L., Higgins, Cassandra B., Heitmeier, Monique R., Kraft, Thomas E., Qian, Xia, Crowley, Jan R., Hyrc, Krzysztof L., Beatty, Wandy L., Yarasheski, Kevin E., Hruz, Paul W., DeBosch, Brian J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138640/
https://ncbi.nlm.nih.gov/pubmed/27922102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38586
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