Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to pathological protein aggregation. Despite decades of ubiquitous use as a nutraceutical, preservative, and humectant, its mechanism of action remains...

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Veröffentlicht in:Sci Signal
Hauptverfasser: DeBosch, Brian J, Heitmeier, Monique R., Mayer, Allyson L., Higgins, Cassandra B., Crowley, Jan R., Kraft, Thomas E., Chi, Maggie, Newberry, Elizabeth P., Chen, Zhouji, Finck, Brian N., Davidson, Nicholas O., Yarasheski, Kevin E., Hruz, Paul W., Moley, Kelle H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816640/
https://ncbi.nlm.nih.gov/pubmed/26905426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aac5472
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