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Upward movement of IS4 and IIIS4 is a rate-limiting stage in Ca(v)1.2 activation
In order to specify the role of individual S4 segments in Ca(V)1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all replacements of charges in IS4 and IIIS4 decrease...
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| Published in: | Pflugers Arch |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer Berlin Heidelberg
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5138263/ https://ncbi.nlm.nih.gov/pubmed/27796578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-016-1895-5 |
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