Coupled and Independent Contributions of Residues in IS6 and IIS6 to Activation Gating of Ca(V)1.2

Voltage dependence and kinetics of Ca(V)1.2 activation are affected by structural changes in pore-lining S6 segments of the α(1)-subunit. Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 (“bundle crossing region”), where S6 segments are...

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Bibliografske podrobnosti
Main Authors: Kudrnac, Michaela, Beyl, Stanislav, Hohaus, Annette, Stary, Anna, Peterbauer, Thomas, Timin, Eugen, Hering, Steffen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Membrane Transport, Structure, Function, and Biogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673296/
https://ncbi.nlm.nih.gov/pubmed/19265197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808402200
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