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Coupled and Independent Contributions of Residues in IS6 and IIS6 to Activation Gating of Ca(V)1.2
Voltage dependence and kinetics of Ca(V)1.2 activation are affected by structural changes in pore-lining S6 segments of the α(1)-subunit. Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 (“bundle crossing region”), where S6 segments are...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673296/ https://ncbi.nlm.nih.gov/pubmed/19265197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808402200 |
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