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Optimal Sequential Enrichment Designs for Phase II Clinical Trials

In the early phase development of molecularly targeted agents (MTAs), a commonly encountered situation is that the MTA is expected to be more effective for a certain biomarker subgroup, say marker-positive patients, but there is no adequate evidence to show that the MTA does not work for the other s...

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Detalhes bibliográficos
Publicado no:Stat Med
Main Authors: Zang, Yong, Yuan, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138118/
https://ncbi.nlm.nih.gov/pubmed/27640874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7128
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