Increased autophagy in CD4(+) T cells of rheumatoid arthritis patients results in T cell hyperactivation and apoptosis resistance

Rheumatoid arthritis (RA) is an autoimmune disease hallmarked by aberrant cellular homeostasis, resulting in hyperactive CD4(+) T cells that are more resistant to apoptosis. Both hyperactivation and resistance to apoptosis may contribute to the pathogenicity of these T cells in the autoimmune proces...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: van Loosdregt, Jorg, Rossetti, Maura, Spreafico, Roberto, Moshref, Maryam, Olmer, Merissa, Williams, Gary W., Venkatanarayanan, Hari Balaji, Kumar, Pavanish, Copeland, Dana, Pischel, Ken, Lotz, Martin, Albani, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138112/
https://ncbi.nlm.nih.gov/pubmed/27624289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201646375
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