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Effect of esomeprazole, a proton pump inhibitor on the pharmacokinetics of sonidegib in healthy volunteers

AIMS: This study aimed to evaluate the impact of esomeprazole on the pharmacokinetics of sonidegib. METHODS: This Phase I study evaluated the impact of the proton pump inhibitor (PPI) esomeprazole on the oral absorption and pharmacokinetics (PKs) of a single dose of sonidegib under fasted conditions...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Zhou, Jocelyn, Quinlan, Michelle, Glenn, Kelli, Boss, Hildegard, Picard, Franck, Castro, Henry, Sellami, Dalila
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137827/
https://ncbi.nlm.nih.gov/pubmed/27277189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13038
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