Effect of a proton pump inhibitor on the pharmacokinetics of imatinib

AIMS: Imatinib mesylate (Gleevec®/Glivec®), which has revolutionized the treatment of chronic myeloid leukemias (CML) and gastrointestinal stromal tumours (GIST), has been reported to cause gastric upset. Consequently, proton pump inhibitors (PPI) are frequently co-administered with imatinib. Becaus...

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Detalhes bibliográficos
Main Authors: Egorin, Merrill J, Shah, Dhvani D, Christner, Susan M, Yerk, Mara A, Komazec, Kristin A, Appleman, Leonard R, Redner, Robert L, Miller, Brian M, Beumer, Jan H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766475/
https://ncbi.nlm.nih.gov/pubmed/19740393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03466.x
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