Effect of antacid on imatinib absorption

PURPOSE: Imatinib often causes gastric upset resulting in frequent co-administration of an antacid. Elevated gastric pH, delayed gastric emptying, or introduction of Mg(2+)/Al(3+) could potentially change imatinib absorption, thereby affecting the therapeutic effectiveness of imatinib. Indeed, antac...

Full description

Saved in:
Bibliographic Details
Main Authors: Sparano, Brian A., Egorin, Merrill J., Parise, Robert A., Walters, Jennifer, Komazec, Kristin A., Redner, Robert L., Beumer, Jan H.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715160/
https://ncbi.nlm.nih.gov/pubmed/18500518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0778-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items