CD98-mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia

Acute myelogenous leukemia (AML) is an aggressive disease associated with drug resistance and relapse. To improve therapeutic strategies, it is critical to better understand the mechanisms that underlie AML progression. Here we show that the integrin binding glycoprotein CD98 plays a central role in...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Bajaj, Jeevisha, Konuma, Takaaki, Lytle, Nikki K., Kwon, Hyog Young, Ablack, Jailal N., Cantor, Joseph M., Rizzieri, David, Chuah, Charles, Oehler, Vivian G., Broome, Elizabeth H., Ball, Edward D., van der Horst, Edward H., Ginsberg, Mark H., Reya, Tannishtha
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137811/
https://ncbi.nlm.nih.gov/pubmed/27908736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.003
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