Dephosphorylation of the Retinoblastoma protein (Rb) inhibits cancer cell EMT via Zeb

The tumor suppressor Retinoblastoma (Rb) protein is highly phosphorylated in cancer cells largely due to the overexpression of cyclins or the loss of expression of cyclin dependent kinase inhibitors (cdki). Hyperphosphorylation of Rb promotes proliferation, and plays a role in the regulation of apop...

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Bibliografiska uppgifter
I publikationen:Cancer Biol Ther
Huvudupphovsmän: Egger, Jacklynn V., Lane, Maria V., Antonucci, Lisa A., Dedi, Brixhilda, Krucher, Nancy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137485/
https://ncbi.nlm.nih.gov/pubmed/27645778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1235668
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