Dephosphorylation of the Retinoblastoma protein (Rb) inhibits cancer cell EMT via Zeb

The tumor suppressor Retinoblastoma (Rb) protein is highly phosphorylated in cancer cells largely due to the overexpression of cyclins or the loss of expression of cyclin dependent kinase inhibitors (cdki). Hyperphosphorylation of Rb promotes proliferation, and plays a role in the regulation of apop...

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Vydáno v:Cancer Biol Ther
Hlavní autoři: Egger, Jacklynn V., Lane, Maria V., Antonucci, Lisa A., Dedi, Brixhilda, Krucher, Nancy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137485/
https://ncbi.nlm.nih.gov/pubmed/27645778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1235668
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