Suppression of triple-negative breast cancer metastasis by pan-DAC inhibitor panobinostat via inhibition of ZEB family of EMT master regulators

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. The epithelial-to-mesenchymal transition (EMT) is a key contributor in the metastatic process. We previously showed the pan-deacetylase inhibitor LBH589 induces CDH1 expression...

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Autori principali: Rhodes, Lyndsay V., Tate, Chandra R., Segar, H. Chris, Burks, Hope E., Phamduy, Theresa B., Hoang, Van, Elliott, Steven, Gilliam, Diari, Pounder, F. Nell, Anbalagan, Muralidharan, Chrisey, Douglas B., Rowan, Brian G., Burow, Matthew E., Collins-Burow, Bridgette M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083690/
https://ncbi.nlm.nih.gov/pubmed/24810497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-014-2979-6
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