Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition

The Retinoblastoma protein (Rb) is important in the control of cell proliferation and apoptosis. Its activity is controlled by reversible phosphorylation on several serine and threonine residues. When Rb is hypophosphorylated, it inhibits proliferation by preventing passage through the G(1)- S phase...

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Autores principales: Lentine, Brandon, Antonucci, Lisa, Hunce, Ray, Edwards, Justina, Marallano, Valerie, Krucher, Nancy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466530/
https://ncbi.nlm.nih.gov/pubmed/22895174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21693
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