Docking-Dependent Regulation of the Rb Tumor Suppressor Protein by Cdk4

Phosphorylation of target proteins by cyclin D1-Cdk4 requires both substrate docking and kinase activity. In addition to the ability of cyclin D1-Cdk4 to catalyze the phosphorylation of consensus sites within the primary amino acid sequence of a substrate, maximum catalytic activity requires the enz...

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Bibliographic Details
Main Authors: Wallace, Maura, Ball, Kathryn L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC419867/
https://ncbi.nlm.nih.gov/pubmed/15169919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.12.5606-5619.2004
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