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Docking-Dependent Regulation of the Rb Tumor Suppressor Protein by Cdk4
Phosphorylation of target proteins by cyclin D1-Cdk4 requires both substrate docking and kinase activity. In addition to the ability of cyclin D1-Cdk4 to catalyze the phosphorylation of consensus sites within the primary amino acid sequence of a substrate, maximum catalytic activity requires the enz...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2004
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419867/ https://ncbi.nlm.nih.gov/pubmed/15169919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.12.5606-5619.2004 |
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