Structural insights into the activation of human relaxin family peptide receptor 1 by small molecule agonists

The GPCR relaxin family peptide receptor 1 (RXFP1) mediates the action of relaxin peptide hormone including its tissue remodeling and antifibrotic effects. The peptide hormone has a short half-life in plasma, limiting its therapeutic utility. However, small molecule agonists of human RXFP1 can overc...

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Bibliografische gegevens
Gepubliceerd in:Biochemistry
Hoofdauteurs: Hu, Xin, Myhr, Courtney, Huang, Zaohua, Xiao, Jingbo, Barnaeva, Elena, Ho, Brian A., Agoulnik, Irina U., Ferrer, Marc, Marugan, Juan J., Southall, Noel, Agoulnik, Alexander I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137375/
https://ncbi.nlm.nih.gov/pubmed/26866459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01195
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