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Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

The anti-fibrotic, vasodilatory, and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases and recent clinical trial data has shown benefit in treating acute heart failure. However, the remodeling capacity of these peptide hormones is...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Xiao, Jingbo, Huang, Zaohua, Chen, Catherine Z., Agoulnik, Irina U., Southall, Noel, Hu, Xin, Jones, Raisa E., Ferrer, Marc, Zheng, Wei, Agoulnik, Alexander I., Marugan, Juan J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915074/
https://ncbi.nlm.nih.gov/pubmed/23764525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2953
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