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Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1
The anti-fibrotic, vasodilatory, and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases and recent clinical trial data has shown benefit in treating acute heart failure. However, the remodeling capacity of these peptide hormones is...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915074/ https://ncbi.nlm.nih.gov/pubmed/23764525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2953 |
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