Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

The anti-fibrotic, vasodilatory, and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases and recent clinical trial data has shown benefit in treating acute heart failure. However, the remodeling capacity of these peptide hormones is...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Xiao, Jingbo, Huang, Zaohua, Chen, Catherine Z., Agoulnik, Irina U., Southall, Noel, Hu, Xin, Jones, Raisa E., Ferrer, Marc, Zheng, Wei, Agoulnik, Alexander I., Marugan, Juan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915074/
https://ncbi.nlm.nih.gov/pubmed/23764525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2953
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