Caricamento...

Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development

Several mutations, located mainly in the MSX1 homeodomain, have been identified in non-syndromic tooth agenesis predominantly affecting premolars and third molars. We identified a novel frameshift mutation of the highly conserved C-terminal domain of MSX1, known as Msx homology domain 6 (MH6), in a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Mitsui, Silvia Naomi, Yasue, Akihiro, Masuda, Kiyoshi, Naruto, Takuya, Minegishi, Yoshiyuki, Oyadomari, Seiichi, Noji, Sumihare, Imoto, Issei, Tanaka, Eiji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137164/
https://ncbi.nlm.nih.gov/pubmed/27917906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38398
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !