Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

A large proportion of melanomas harbour the activating BRAF(V600E) mutation that renders these cells dependent on MAPK signalling for their survival. Although the highly specific and clinically approved BRAF(V600E) kinase inhibitor, PLX4032, induces apoptosis of melanoma cells bearing this mutation,...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Rohrbeck, Leona, Gong, Jia-Nan, Lee, Erinna F, Kueh, Andrew J, Behren, Andreas, Tai, Lin, Lessene, Guillaume, Huang, David C S, Fairlie, Walter D, Strasser, Andreas, Herold, Marco J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136498/
https://ncbi.nlm.nih.gov/pubmed/27689874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.96
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