Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

A large proportion of melanomas harbour the activating BRAF(V600E) mutation that renders these cells dependent on MAPK signalling for their survival. Although the highly specific and clinically approved BRAF(V600E) kinase inhibitor, PLX4032, induces apoptosis of melanoma cells bearing this mutation,...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: Rohrbeck, Leona, Gong, Jia-Nan, Lee, Erinna F, Kueh, Andrew J, Behren, Andreas, Tai, Lin, Lessene, Guillaume, Huang, David C S, Fairlie, Walter D, Strasser, Andreas, Herold, Marco J
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136498/
https://ncbi.nlm.nih.gov/pubmed/27689874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.96
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