ロード中...
Mutant BRAF upregulates MCL-1 to confer apoptosis resistance that is reversed by MCL-1 antagonism and cobimetinib in colorectal cancer
Oncogenic BRAF(V600E) mutations activate MAP kinase signaling and are associated with treatment resistance and poor prognosis in patients with colorectal cancer (CRC). In BRAF(V600E) mutant CRCs, treatment failure may be related to BRAF(V600E) -mediated apoptosis resistance that occurs by an as yet...
保存先:
| 出版年: | Mol Cancer Ther |
|---|---|
| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5136313/ https://ncbi.nlm.nih.gov/pubmed/27765849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0017 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|