The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism

In colorectal cancers with oncogenic GTPase Kras (KRAS) mutations, inhibition of downstream MEK/ERK signaling has shown limited efficacy, in part because of failure to induce a robust apoptotic response. We studied the mechanism of apoptosis resistance in mutant KRAS cells and sought to enhance the...

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Опубликовано в: :J Biol Chem
Главные авторы: Zaanan, Aziz, Okamoto, Koichi, Kawakami, Hisato, Khazaie, Khashayarsha, Huang, Shengbing, Sinicrope, Frank A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583008/
https://ncbi.nlm.nih.gov/pubmed/26245900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657833
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