Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53

Doxorubicin and other anthracycline compounds exert their anti-cancer effects by causing DNA damage and initiating cell cycle arrest in cancer cells, followed by apoptosis. DNA damage generally activates a p53-mediated pathway to initiate apoptosis by increasing the level of the BH3-only protein, Pu...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Yang, Min-Chi, Lin, Ru-Wei, Huang, Shih-Bo, Huang, Shin-Yuan, Chen, Wen-Jie, Wang, Shiaw, Hong, Yi-Ren, Wang, Chihuei
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943702/
https://ncbi.nlm.nih.gov/pubmed/26694174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1127470
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