P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage

We previously demonstrated that Bim is the main BH3-only protein replacing Bak/Bax from Bcl-xl to activate apoptosis in a p53-independent manner in response to doxorubicin in prostate cancer. However, the comparison of doxorubicin treatment between LNCaP cells carrying p53-wild type and PC3 cells ca...

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Publicat a:Cell Cycle
Autors principals: Lin, Ru-Wei, Ho, Cheng-Jung, Chen, Hsin-Wen, Pao, Yu-Hsuan, Chen, Li-En, Yang, Min-Chi, Huang, Shih-Bo, Wang, Shiaw, Chen, Chung-Hwan, Wang, Chihuei
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226221/
https://ncbi.nlm.nih.gov/pubmed/30198376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1520565
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