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Reversal of Mutant KRAS-mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer

KRAS mutations are frequently detected in human colorectal cancer (CRC) and contribute to de novo apoptosis resistance and ultimately therapeutic failure. To overcome KRAS-mediated apoptosis resistance, the irreversible proteasome inhibitor, carfilzomib, was evaluated and found to potently induce No...

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Опубликовано в: :Mol Cancer Res
Главные авторы: Okamoto, Koichi, Zaanan, Aziz, Kawakami, Hisato, Huang, Shengbing, Sinicrope, Frank A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398608/
https://ncbi.nlm.nih.gov/pubmed/25548100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0476
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