mTORC2 signaling drives the development and progression of pancreatic cancer

mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex. However, clinical trials of mTORC1 inhibitors in pancreatic cancer have failed, raising questions about th...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Driscoll, David R, Karim, Saadia A, Sano, Makoto, Gay, David M, Jacob, Wright, Yu, Jun, Mizukami, Yusuke, Gopinathan, Aarthi, Jodrell, Duncan I, Evans, TR Jeffry, Bardeesy, Nabeel, Hall, Michael N, Quattrochi, Brian J., Klimstra, David S., Barry, Simon T, Sansom, Owen J, Lewis, Brian C, Morton, Jennifer P
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135633/
https://ncbi.nlm.nih.gov/pubmed/27758884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0810
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