mTORC2 signaling drives the development and progression of pancreatic cancer

mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex. However, clinical trials of mTORC1 inhibitors in pancreatic cancer have failed, raising questions about th...

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Vydáno v:Cancer Res
Hlavní autoři: Driscoll, David R, Karim, Saadia A, Sano, Makoto, Gay, David M, Jacob, Wright, Yu, Jun, Mizukami, Yusuke, Gopinathan, Aarthi, Jodrell, Duncan I, Evans, TR Jeffry, Bardeesy, Nabeel, Hall, Michael N, Quattrochi, Brian J., Klimstra, David S., Barry, Simon T, Sansom, Owen J, Lewis, Brian C, Morton, Jennifer P
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135633/
https://ncbi.nlm.nih.gov/pubmed/27758884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0810
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