Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma

Janus kinases (JAKs) classically signal by activating STAT transcription factors but can also regulate gene expression by epigenetically phosphorylating histone H3 on tyrosine 41 (H3Y41-P). In diffuse large B-cell lymphomas (DLBCLs), JAK signaling is a feature of the activated B-cell (ABC) subtype a...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Rui, Lixin, Drennan, Amanda C., Ceribelli, Michele, Zhu, Fen, Wright, George W., Huang, Da Wei, Xiao, Wenming, Li, Yangguang, Grindle, Kreg M., Lu, Li, Hodson, Daniel J., Shaffer, Arthur L., Zhao, Hong, Xu, Weihong, Yang, Yandan, Staudt, Louis M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135360/
https://ncbi.nlm.nih.gov/pubmed/27799566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610970113
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