Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2

The requirement for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germinal center B cells has proved controversial. Here, we report that germinal center B cells are formed normally after depletion of OCT2 in a conditional knockout mouse, but their proliferati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hodson, Daniel J., Shaffer, Arthur L., Xiao, Wenming, Wright, George W., Schmitz, Roland, Phelan, James D., Yang, Yandan, Webster, Daniel E., Rui, Lixin, Kohlhammer, Holger, Nakagawa, Masao, Waldmann, Thomas A., Staudt, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833274/
https://ncbi.nlm.nih.gov/pubmed/26993806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600557113
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