Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2

The requirement for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germinal center B cells has proved controversial. Here, we report that germinal center B cells are formed normally after depletion of OCT2 in a conditional knockout mouse, but their proliferati...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hodson, Daniel J., Shaffer, Arthur L., Xiao, Wenming, Wright, George W., Schmitz, Roland, Phelan, James D., Yang, Yandan, Webster, Daniel E., Rui, Lixin, Kohlhammer, Holger, Nakagawa, Masao, Waldmann, Thomas A., Staudt, Louis M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833274/
https://ncbi.nlm.nih.gov/pubmed/26993806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600557113
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