Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

Protein kinase A (PKA) phosphorylates Gli proteins, acting as a negative regulator of the Hedgehog pathway. PKA was recently detected within the cilium, and PKA activity specifically in cilia regulates Gli processing. Using a cilia-targeted genetically encoded sensor, we found significant basal PKA...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Moore, Bryn S., Stepanchick, Ann N., Tewson, Paul H., Hartle, Cassandra M., Zhang, Jin, Quinn, Anne Marie, Hughes, Thomas E., Mirshahi, Tooraj
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135322/
https://ncbi.nlm.nih.gov/pubmed/27799542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602393113
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
Načítá se...

Podobné jednotky