Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

Primary cilia are present on mammalian neurons and glia, but their function is largely unknown. We generated conditional homozygous mutant mice for a gene we termed Stumpy. Mutants lack cilia and have conspicuous abnormalities in postnatally developing brain regions, including a hypoplasic hippocamp...

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Auteurs principaux: Breunig, Joshua J., Sarkisian, Matthew R., Arellano, Jon I., Morozov, Yury M., Ayoub, Albert E., Sojitra, Sonal, Wang, Baolin, Flavell, Richard A., Rakic, Pasko, Town, Terrence
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529104/
https://ncbi.nlm.nih.gov/pubmed/18728187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804558105
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