Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

Primary cilia are present on mammalian neurons and glia, but their function is largely unknown. We generated conditional homozygous mutant mice for a gene we termed Stumpy. Mutants lack cilia and have conspicuous abnormalities in postnatally developing brain regions, including a hypoplasic hippocamp...

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Detalhes bibliográficos
Main Authors: Breunig, Joshua J., Sarkisian, Matthew R., Arellano, Jon I., Morozov, Yury M., Ayoub, Albert E., Sojitra, Sonal, Wang, Baolin, Flavell, Richard A., Rakic, Pasko, Town, Terrence
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529104/
https://ncbi.nlm.nih.gov/pubmed/18728187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804558105
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