Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

Primary cilia are present on mammalian neurons and glia, but their function is largely unknown. We generated conditional homozygous mutant mice for a gene we termed Stumpy. Mutants lack cilia and have conspicuous abnormalities in postnatally developing brain regions, including a hypoplasic hippocamp...

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Autori principali: Breunig, Joshua J., Sarkisian, Matthew R., Arellano, Jon I., Morozov, Yury M., Ayoub, Albert E., Sojitra, Sonal, Wang, Baolin, Flavell, Richard A., Rakic, Pasko, Town, Terrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529104/
https://ncbi.nlm.nih.gov/pubmed/18728187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804558105
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