Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

Protein kinase A (PKA) phosphorylates Gli proteins, acting as a negative regulator of the Hedgehog pathway. PKA was recently detected within the cilium, and PKA activity specifically in cilia regulates Gli processing. Using a cilia-targeted genetically encoded sensor, we found significant basal PKA...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Moore, Bryn S., Stepanchick, Ann N., Tewson, Paul H., Hartle, Cassandra M., Zhang, Jin, Quinn, Anne Marie, Hughes, Thomas E., Mirshahi, Tooraj
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2016
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135322/
https://ncbi.nlm.nih.gov/pubmed/27799542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602393113
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