Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes

The adaptive immune repertoire plays a critical role in type 1 diabetes (T1D) pathogenesis. However, efforts to characterize B cell and T cell receptor (TCR) profiles in T1D subjects have been largely limited to peripheral blood sampling and restricted to known antigens. To address this, we collecte...

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Foilsithe in:JCI Insight
Main Authors: Seay, Howard R., Yusko, Erik, Rothweiler, Stephanie J., Zhang, Lin, Posgai, Amanda L., Campbell-Thompson, Martha, Vignali, Marissa, Emerson, Ryan O., Kaddis, John S., Ko, Dave, Nakayama, Maki, Smith, Mia J., Cambier, John C., Pugliese, Alberto, Atkinson, Mark A., Robins, Harlan S., Brusko, Todd M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135280/
https://ncbi.nlm.nih.gov/pubmed/27942583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88242
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