Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Immune checkpoint therapies, such as ipilimumab, induce dramatic antitumor responses in a subset of patients with advanced malignancies, but they may also induce inflammatory responses and toxicities termed immune-related adverse events (irAEs). These irAEs are often low grade and manageable, but se...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Subudhi, Sumit K., Aparicio, Ana, Gao, Jianjun, Zurita, Amado J., Araujo, John C., Logothetis, Christopher J., Tahir, Salahaldin A., Korivi, Brinda R., Slack, Rebecca S., Vence, Luis, Emerson, Ryan O., Yusko, Erik, Vignali, Marissa, Robins, Harlan S., Sun, Jingjing, Allison, James P., Sharma, Padmanee
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081579/
https://ncbi.nlm.nih.gov/pubmed/27698113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611421113
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