Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Immune checkpoint therapies, such as ipilimumab, induce dramatic antitumor responses in a subset of patients with advanced malignancies, but they may also induce inflammatory responses and toxicities termed immune-related adverse events (irAEs). These irAEs are often low grade and manageable, but se...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Subudhi, Sumit K., Aparicio, Ana, Gao, Jianjun, Zurita, Amado J., Araujo, John C., Logothetis, Christopher J., Tahir, Salahaldin A., Korivi, Brinda R., Slack, Rebecca S., Vence, Luis, Emerson, Ryan O., Yusko, Erik, Vignali, Marissa, Robins, Harlan S., Sun, Jingjing, Allison, James P., Sharma, Padmanee
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081579/
https://ncbi.nlm.nih.gov/pubmed/27698113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611421113
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