Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Immune checkpoint therapies, such as ipilimumab, induce dramatic antitumor responses in a subset of patients with advanced malignancies, but they may also induce inflammatory responses and toxicities termed immune-related adverse events (irAEs). These irAEs are often low grade and manageable, but se...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Subudhi, Sumit K., Aparicio, Ana, Gao, Jianjun, Zurita, Amado J., Araujo, John C., Logothetis, Christopher J., Tahir, Salahaldin A., Korivi, Brinda R., Slack, Rebecca S., Vence, Luis, Emerson, Ryan O., Yusko, Erik, Vignali, Marissa, Robins, Harlan S., Sun, Jingjing, Allison, James P., Sharma, Padmanee
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081579/
https://ncbi.nlm.nih.gov/pubmed/27698113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611421113
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