Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Immune checkpoint therapies, such as ipilimumab, induce dramatic antitumor responses in a subset of patients with advanced malignancies, but they may also induce inflammatory responses and toxicities termed immune-related adverse events (irAEs). These irAEs are often low grade and manageable, but se...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Subudhi, Sumit K., Aparicio, Ana, Gao, Jianjun, Zurita, Amado J., Araujo, John C., Logothetis, Christopher J., Tahir, Salahaldin A., Korivi, Brinda R., Slack, Rebecca S., Vence, Luis, Emerson, Ryan O., Yusko, Erik, Vignali, Marissa, Robins, Harlan S., Sun, Jingjing, Allison, James P., Sharma, Padmanee
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081579/
https://ncbi.nlm.nih.gov/pubmed/27698113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611421113
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