Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Immune checkpoint therapies, such as ipilimumab, induce dramatic antitumor responses in a subset of patients with advanced malignancies, but they may also induce inflammatory responses and toxicities termed immune-related adverse events (irAEs). These irAEs are often low grade and manageable, but se...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Subudhi, Sumit K., Aparicio, Ana, Gao, Jianjun, Zurita, Amado J., Araujo, John C., Logothetis, Christopher J., Tahir, Salahaldin A., Korivi, Brinda R., Slack, Rebecca S., Vence, Luis, Emerson, Ryan O., Yusko, Erik, Vignali, Marissa, Robins, Harlan S., Sun, Jingjing, Allison, James P., Sharma, Padmanee
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081579/
https://ncbi.nlm.nih.gov/pubmed/27698113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611421113
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