A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive Alpha-dicarbonyl Detoxification

Reactive α-dicarbonyls (α-DCs), like methylglyoxal (MGO) accumulate with age, and have been implicated in aging and various age-associated pathologies such as diabetic complications and neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Evolutionarily conserved glyoxalases are...

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Udgivet i:Curr Biol
Main Authors: Chaudhuri, Jyotiska, Bose, Neelanjan, Gong, Jianke, Hall, David, Rifkind, Alexander, Bhaumik, Dipa, Peiris, T. Harshani, Chamoli, Manish, Le, Catherine H., Liu, Jianfeng, Lithgow, Gordon J., Ramanathan, Arvind, Shawn Xu, X. Z., Kapahi, Pankaj
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135008/
https://ncbi.nlm.nih.gov/pubmed/27773573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.09.024
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