Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra‐3/daf‐11 signaling in Caenorhabditis elegans

In the nematode Caenorhabditis elegans, signals derived from bacteria in the diet, the animal's major nutrient source, can modulate both behavior and healthspan. Here we describe a dual role for trimethylamine (TMA), a human gut flora metabolite, which acts as a nutrient signal and a neurotoxin...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Khanna, Amit, Sellegounder, Durai, Kumar, Jitendra, Chamoli, Manish, Vargas, Miguel, Chinta, Shankar J., Rane, Anand, Nelson, Christopher, Peiris, T. Harshani, Brem, Rachel, Andersen, Julie, Lithgow, Gordon, Kapahi, Pankaj
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135002/
https://ncbi.nlm.nih.gov/pubmed/33819374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13351
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