Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be ta...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Javaheri, Tahereh, Kazemi, Zahra, Pencik, Jan, Pham, Ha TT, Kauer, Maximilian, Noorizadeh, Rahil, Sax, Barbara, Nivarthi, Harini, Schlederer, Michaela, Maurer, Barbara, Hofbauer, Maximillian, Aryee, Dave NT, Wiedner, Marc, Tomazou, Eleni M, Logan, Malcolm, Hartmann, Christine, Tuckermann, Jan P, Kenner, Lukas, Mikula, Mario, Dolznig, Helmut, Üren, Aykut, Richter, Günther H, Grebien, Florian, Kovar, Heinrich, Moriggl, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133963/
https://ncbi.nlm.nih.gov/pubmed/27735950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.268
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