Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be ta...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Javaheri, Tahereh, Kazemi, Zahra, Pencik, Jan, Pham, Ha TT, Kauer, Maximilian, Noorizadeh, Rahil, Sax, Barbara, Nivarthi, Harini, Schlederer, Michaela, Maurer, Barbara, Hofbauer, Maximillian, Aryee, Dave NT, Wiedner, Marc, Tomazou, Eleni M, Logan, Malcolm, Hartmann, Christine, Tuckermann, Jan P, Kenner, Lukas, Mikula, Mario, Dolznig, Helmut, Üren, Aykut, Richter, Günther H, Grebien, Florian, Kovar, Heinrich, Moriggl, Richard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133963/
https://ncbi.nlm.nih.gov/pubmed/27735950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.268
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