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Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be ta...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Javaheri, Tahereh, Kazemi, Zahra, Pencik, Jan, Pham, Ha TT, Kauer, Maximilian, Noorizadeh, Rahil, Sax, Barbara, Nivarthi, Harini, Schlederer, Michaela, Maurer, Barbara, Hofbauer, Maximillian, Aryee, Dave NT, Wiedner, Marc, Tomazou, Eleni M, Logan, Malcolm, Hartmann, Christine, Tuckermann, Jan P, Kenner, Lukas, Mikula, Mario, Dolznig, Helmut, Üren, Aykut, Richter, Günther H, Grebien, Florian, Kovar, Heinrich, Moriggl, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133963/
https://ncbi.nlm.nih.gov/pubmed/27735950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.268
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